Nurosym tVNS device

DETAILS

What is Nurosym?

Nurosym is a clinically validated and certified, patented medical device designed for neuromodulation.

Nurosym uses proven tVNS technology to modulate the nervous system and restore neural network function by targeting the vagus nerve to send specially designed signals to the brain to alter physical and mental states and restore health.

This innovative technology provides beneficial effects for atrial fibrillation, anxiety, depression, stress and chronic fatigue. In addition, further research is ongoing to evaluate multiple applications of Nurosym.

Nurosym is a clinically validated and certified medical device that can be used in the comfort of your home. It offers a non-invasive and drug-free alternative to improve patients' quality of life.

How does Nurosym work?

The Nurosym device modulates the autonomic nervous system through the vagus nerve, restoring optimal balance.

The autonomic nervous system is the subconscious part of the peripheral nervous system that regulates the function of the internal organs (such as the heart, lungs and digestive system) and "orchestrates" the interactions between different physiological systems (such as the immune and cardiovascular systems) in response to external and internal stimuli.

The autonomic nervous system is composed of two parts, the parasympathetic (rest and digest) and sympathetic (flight or fight) nervous systems, which exert different and often opposing effects on organ function (including respiration rate, pupil dilation, salivary secretion, digestion, peristalsis and sexual arousal).

Dysfunctions of the autonomic nervous system, or dysautonomia, which result in increased sympathetic activity and suppressed parasympathetic activity, are known and documented in a wide range of chronic physical, psychiatric and neurological conditions.

By targeting the vagus nerve, Nurosym is able to stimulate and enhance parasympathetic activity, thereby promoting optimal autonomic nervous system balance and restoring healthy neurophysiological networks.

What is the vagus nerve?

The vagus nerve, also known as the tenth cranial nerve or vagus nerve, is an important part of the peripheral nervous system. 

It belongs to the so-called parasympathetic nervous system, which is responsible for regulating relaxation, rest and regeneration. The vagus nerve is the longest nerve in the body and extends from the brain to the organs in the abdominal cavity.

The main function of the vagus nerve is to provide a link between the brain and various organs of the body, including the heart, lungs, gastrointestinal tract and internal organs. The vagus nerve plays a crucial role in regulating heart rhythm, respiration, digestion and metabolism.

As part of the parasympathetic nervous system, the vagus nerve acts as the antipole of the sympathetic nervous system, responsible for activating the body and preparing it for physical or emotional stress. It has a calming effect on the body and promotes relaxation, regeneration and balance in the autonomic nervous system.

In addition, the vagus nerve plays an important role in regulating the immune system, inflammatory responses and mood. By stimulating the vagus nerve, certain therapeutic effects can be achieved, including reduced inflammation, improved mood and general well-being.

What is tVNS?

Transcutaneous electrical vagus nerve stimulation (tVNS) is the stimulation of the vagus nerve through the skin.

It is delivered by electrical impulses to the tragus, the front of the outer ear. This stimulation has the ability to modulate the vagus nerve and can have a variety of positive effects on the body, such as regulating heart rhythm, reducing inflammation and improving overall health.

What is neuromodulation?

Neuromodulation is a technology that works directly on the nerves. It is the alteration - or modulation - of nerve activity by the direct delivery of electricity or drugs to a target area.

Neuromodulation devices and treatments can be life-changing. They affect every area of the body and treat almost every ailment or symptom from headaches to tremors to spinal cord damage to urinary incontinence. With such a wide therapeutic scope and with significant ongoing advances in biotechnology, it is not surprising that neuromodulation promises to be one of the most promising methods of the next decade.

Neuromodulation is most often thought of in the context of chronic pain relief, which is the most common indication today.

However, there are many applications of neuromodulation, such as deep brain stimulation (DBS) for the treatment of Parkinson's disease, sacral nerve stimulation for the treatment of pelvic disorders and incontinence, and spinal cord stimulation for the treatment of ischemic disorders (angina, peripheral vascular disease).

In addition, neuromodulation devices can trigger responses that were not previously possible, such as a cochlear implant to restore hearing in a deaf patient.

The most recent application is vagus stimulation via the tragus (tVNS), which has been shown to have beneficial effects in atrial fibrillation, depression, anxiety, post-covid, long-covid, rheumatoid arthritis and chronic fatigue syndromes.

A growing number of disorders can be treated with neuromodulation.

What conditions are recommended?

The Nurosym system has been validated in more than 30 published clinical studies demonstrating the efficacy of its technology across a wide range of diseases.

• Nurosym has been shown to improve heart rate variability (HRV), a measure of heart rate variability. Higher HRV is generally associated with health, fitness, and even healthier stress or emotional foundations, while low HRV is associated with risk factors such as morbidity, mortality and stress. Low HRV has been observed in a number of diseases, including chronic cardiovascular disease and conditions associated with autonomic nervous system dysfunction.
• Nurosym downregulates unhealthy immune response mechanisms by restoring autonomic tone through activation of the cholinergic anti-inflammatory pathway (CAP). It stimulates the release of the neurotransmitter acetylcholine, which attenuates the production of pro-inflammatory cytokines and restores healthy nitric oxide production, which in turn improves endothelial function when impaired by excessive sympathetic activity. 
  Placebo-controlled, randomised clinical trials have documented a reduction in levels of inflammatory cytokines, including tumour necrosis factor alpha (TNF-α), C-reactive protein and interleukin IL-8, as a result of Parasym neuromodulation in patients with elevated baseline levels of these inflammatory cytokines. This is particularly useful in diseases whose pathophysiological root lies in systemic inflammation, excessive sympathetic responses and associated pathological immunological responses.

The most common applications

• Pitvar fibrillation
• Chronic fatigue
• Long covid
• Depression
• Anxiety
• Rheumatoid arthritis

In which cases should the device not be used?

Nurosym is not recommended in the following cases:

• Patients with an active implanted medical device such as a pacemaker, hearing aid implant, or an implanted metal or electronic device.
• Patients with a metal implant in the ear electrode placement area of the left ear. Treatment can also be performed in the right ear with a suitable earphone (on request).
• Other patients with a history of heart disease or atherosclerotic cardiovascular disease, including heart failure, known severe coronary artery disease, or recent heart attack (myocardial infarction; within 5 years).
• Patients diagnosed with a low heart rate, i.e. bradycardia, with a heart rate below 50 beats/minute at baseline.
• Other patients who have undergone surgery to cut the cervical nerve (cervical vagotomy).
• Oly patients who have been diagnosed with carotid artery stenosis (carotid atherosclerosis).
• Patients who have a pain syndrome but the cause has not yet been diagnosed.
• Patients in paediatrics (under 18 years).
• Pregnant women.

Possible risks of using Nurosym

Nurosym is a low-risk device when used according to the instructions for use.

Adverse reactions are generally rare, mild and resolve shortly after treatment is stopped. The most common side effect is skin irritation (tingling/pain/itching/itching). There is a low incidence at the site of electrode application during long-term use.

No serious side effects have been reported.

Nurosym is designed with specific safety features that minimise the risk of use. If Nurosym is used continuously at high intensities (beyond the point where it is uncomfortable or painful), there is a risk of skin itching at the site of stimulation. This risk is low due to the safety features of Nurosym and the discomfort that may occur if the intensity is too high.

Other rare risks of this type of technology may include dizziness, fatigue, shortness of breath, headache and heart rhythm disturbance.

 If you experience any side effects while using Nurosym, stop treatment. If in doubt, consult your doctor or healthcare professional.